KAUFMAN, Michael D.,FLYNN, Daniel L,AHN, Yu Mi,VOGETI, Lakshminarayana,CALDWELL, Timothy Malcolm
申请号：
ES14764032
公开号：
ES2651165T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula I, ** Formula ** or a pharmaceutically acceptable salt, enantiomer, stereoisomer or tautomer thereof, wherein A is taken from the group consisting of -N (R2) R3 and G； G is selected from the group consisting of and where the symbol (**) is the anchor point of the pyrimidine ring； each residue G can be further substituted with one, two or three residues R4； W is a C5-C6 heteroaryl, phenyl, -NHC (O) R6, -NHC (O) R7, -NHC (O) N (R8) R9 or -C (O) N (R8) R9, and in which each C5-C6 heteroaryl or phenyl is optionally substituted by one, two or three R5 moieties； X1 and X2 are individually and independently hydrogen or a C1-C6 alkyl； R1 is hydrogen, C1-C6 alkyl, deuterium-C1-C6 alkyl, wherein the alkyl chain is partially or completely deuterated, or a C3-C8 branched alkyl； R2 is hydrogen, C1-C6 alkyl, deuterium-C1-C6 alkyl in which the alkyl chain is partially or completely deuterated, C3-C8 branched alkyl, C3-C8 cycloalkyl, fluoro-C1-C6 alkyl in which the alkyl is completely or partially fluorinated, - (CH2) m-OR8, or a 3-8 membered heterocyclic ring, in which each alkylene is optionally substituted with a C1-C4 alkyl； R3 is hydrogen, C1-C6 alkyl, deuterium-C1-C6 alkyl in which the alkyl chain is partially or completely deuterated, C3-C8 branched alkyl, C3-C8 cycloalkyl, fluoro-C1-C6 alkyl in which the alkyl is completely or partially fluorinated or a 3-8 membered heterocyclic ring； each R4 is individually and independently hydrogen, halogen, C1-C6 alkyl, fluoro-C1-C6 alkyl in which the alkyl chain is partially or completely fluorinated, C3-C8 branched alkyl, C3-C8 cycloalkyl, - (CH2) m -OR8, - (CH2) m-NR8 (R9), - (CH2) m-R7 or cyano, in which each alkylene is optionally substituted with a C1-C4 alkyl； each R5 is individually and independently hydrogen, C1-C6 alkyl, deuterium-C1-C6 alkyl in which the alkyl chain is partially or completely deuterated, C3-C8 branched alkyl, halogen, cyano, fluoro-C1-C6 alkyl in the that the alkyl chain is partially or
