CID-NUNEZ, JOSE MARIA,MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS,TRABANCO-SUAREZ, ANDRES AVELINO,KOUKNI, MOHAMED,HOORNAERT, GEORGES JOSEPH CORNELIUS,COMPERNOLLE, FRANS JOSEF CORNELIUS,KOZLECKI, TOMASZ
申请号：
CA2588760
公开号：
CA2588760C
申请日:
2005.12.06
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
This invention concerns substituted tetracyclic tetrahydrofuran, pyrrolidineandtetrahydrothiophene derivatives with binding affinities towards serotoninreceptors, inparticular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, inparticulardopamine D2 receptors and with norepinephrine reuptake inhibition properties,pharmaceutical compositions comprising the compounds according to theinvention, the usethereof as a medicine, in particular for the prevention and/or treatment of arange ofpsychiatric and neurological disorders, in particular certain psychotic,cardiovascular andgastrokinetic disorders and processes for their production. The compoundsaccording to theinvention can be represented by general Formula (I) and comprises also thepharmaceuticallyacceptable acid or base addition salts thereof, the stereochemically isomericforms thereof,the N-oxide form thereof and prodrugs thereof.(see formula I)
