CID-NUNEZ, JOSE MARIA,MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS,TRABANCO-SUAREZ, ANDRES AVELINO,KOUKNI, MOHAMED,HOORNAERT, GEORGES JOSEPH CORNELIUS,COMPERNOLLE, FRANS JOSEF CORNELIUS,KOZLECKI, TOMASZ
申请号：
AU2011202995
公开号：
AU2011202995B2
申请日:
2011.06.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT 2c receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition 10 properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (1) (R9i A B (R9j 20 and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
