José Maria Núñez;Antonius Adrianus Hendrikus Petrus Megens;Andrés Avelino Trabanco-Suárez
发明人:
José Maria Núñez,Antonius Adrianus Hendrikus Petrus Megens,Andrés Avelino Trabanco-Suárez
申请号：
US13214344
公开号：
US20120035170A1
申请日:
2011.08.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production.The compounds according to the invention can be represented by general Formula (I)and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in claim 1.
