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FORMULATIONS PHARMACEUTIQUES
专利权人:
MOREX DEVELOPMENT PARTNERS LLP
发明人:
BEATTIE, CHRIS,RENNIE, JAMES,WADSWORTH, ANNE
申请号:
CA2890271
公开号:
CA2890271A1
申请日:
2013.11.22
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The invention provides a pharmaceutical composition comprising (a) a compound of the formula (1), wherein R1, R2, R3 and R4 are substituents, at least one of which contains a carborane cluster; and M is selected from two hydrogen ions and one or two metal ions, wherein any metal ions present are charge-balanced by one or more counter ions; and (b) a vehicle comprising: (i) dimethylacetamide as solvent; and (ii) a co-solvent comprising one or more of tetraglycol; propylene glycol; polyethylene glycol; and a non-ionic surfactant. The pharmaceutical compositions are useful as radiation sensitizers in radiation treatment of cancers.
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