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AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE
专利权人:
发明人:
MORTHALA RAGHAVENDAR RAO,ROY ARNAB,MAITY TAPAS,PATLOLLA BASWARAJ,RAJAPPA MURALI,MAJUMADER NILANJAN,PATEL CHIRAG,KRISHNAMURTHY DHILEEPKUMAR
申请号:
IN3380/MUM/2015
公开号:
IN2015MU03380A
申请日:
2015.09.03
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
The present invention provides an improved process for the prepatipn_of Jstprotected ((3S54R)-4-(4-fluorophenyl)piperidin-3- yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B) followed by reduction of (B) in the presence of a reducing agent to provide compound (A).
来源网站:
中国工程科技知识中心
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