AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE

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专利权人:

发明人:

MORTHALA RAGHAVENDAR RAO,ROY ARNAB,MAITY TAPAS,PATLOLLA BASWARAJ,RAJAPPA MURALI,MAJUMADER NILANJAN,PATEL CHIRAG,KRISHNAMURTHY DHILEEPKUMAR

申请号：

IN3380/MUM/2015

公开号：

IN2015MU03380A

申请日:

2015.09.03

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention provides an improved process for the prepatipn_of Jstprotected ((3S54R)-4-(4-fluorophenyl)piperidin-3- yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B) followed by reduction of (B) in the presence of a reducing agent to provide compound (A).

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