PROBLEM TO BE SOLVED: To suppress release of a drug in the oral cavity and reduce the bitterness in a disintegrating tablet in the oral cavity of the drug having the bitterness.SOLUTION: The disintegrating tablet in the oral cavity with reduced bitterness is a mixed compression molded product of (a) a drug-containing granule prepared by granulating or coating the drug mixed with an excipient and having the bitterness with a film-forming polymer insoluble in water but soluble in a digestive fluid and (b) a drug-uncontaining granule obtained by granulating or coating a saccharide or a sugar alcohol with a water-insoluble hydrophilic granulating ingredient.COPYRIGHT: (C)2005,JPO&NCIPI【課題】苦味を有する薬物の口腔内崩壊錠剤において薬物の口腔内放出を抑制し、苦味を低減させる。【解決手段】(a)賦形剤と混合した苦味を有する薬物を水に不溶であるが消化液に可溶なフィルム形成性ポリマーで造粒もしくは被覆してなる薬物含有顆粒、及び(b)糖または糖アルコールを水に不溶であるが親水性の造粒成分で造粒もしくは被覆してなる薬物不含顆粒、との混合圧縮成形物である、苦味を低減した口腔内崩壊錠剤。【選択図】 なし
