PROBLEM TO BE SOLVED: To reduce bitterness of an orally disintegrating tablet containing a medicament having an unpleasant taste such as the bitterness.SOLUTION: The orally disintegrating tablet with the reduced unpleasant taste such as the bitterness is a mixed and compression-molded product of (a) a medicament-containing granules obtained by granulating or covering the medicament mixed with a vehicle, with ethylcellulose, and (b) medicament-free granules obtained by granulating or covering a sugar and a sugar alcohol with a granulation component which is insoluble in water but hydrophilic.COPYRIGHT: (C)2005,JPO&NCIPI【課題】 苦味などの不快な味を有する薬物を含む口腔内崩壊錠剤の苦味を低減する。【解決手段】 (a)賦形剤と混合した薬物をエチルセルロースで造粒もしくは被覆してなる薬物含有顆粒、及び(b)糖および糖アルコールを水に不溶であるが親水性の造粒成分で造粒もしくは被覆してなる薬物不含顆粒、との混合圧縮成形物である、苦味などの不快な味を低減した口腔内崩壊錠剤。【選択図】 なし
