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Modulators of metabotropic glutamate receptors
专利权人:
MERZ PHARMA GMBH & CO. KGAA
发明人:
ZEMRIBO RONALDS,HENRICH MARKUS,ABEL ULRICH,MULLER SIBYLLE,KUBAS HOLGER,MEYER UDO,HECHENBERGER MIRKO,KAUSS VALERJANS
申请号:
ARP110103856
公开号:
AR083475A1
申请日:
2011.10.18
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
3. Preparation process of the compound. These compounds are mGluR5 modulators, and thus contribute to the control and prevention of acute and / or chronic neurological disorders. Requires 1: a compound selected from formula (1), wherein R1 represents arithmetic, heteromorphic, c3-12-cyclododecyl, c5-12-cyclododecyl, or heterocyclic bicycle; R2 represents hydrogen, fluorine or C1-6 tar; R3 represents hydrogen, fluorine or C1-6 tar; or R2 and R3, together with the carbon atoms connected to them, form a ring of 3 to 7 members, which may be saturated or unsaturated,In the ring, one or two heteroatoms selected from sulfur, oxygen and nitrogen can be selected, and one or more substitutes selected from halogen, fluoromethyl, difluoromethane, trifluoroid, trifluoroisoxic, C1-6 hydrocarbon, alcox C1-6, amino, hydroxy and cyanogen can be selected to replace the ring, ACIO, lease C1-6, di - (C1-6 tar) ammonia, C1-6 tar and oxo; W for CH2, cr4r5ch2 -,Or, s, cr6r7oNR8, or -CR9R10NR11-;And represents cr122r13 or nr14; R4 represents hydrogen, fluorine or C1-6 tar; R5 represents hydrogen, fluorine or C1-6 tar; or R4 and R5, together with the carbon atoms connected with them, form a ring of 3 to 7 members, which may be saturated or unsaturated, In the ring, one or two heteroatoms selected from sulfur, oxygen and nitrogen can be selected, and one or more substitutes selected from halogen, fluoromethyl, difluoromethane, trifluoroid, trifluoroisoxic, C1-6 hydrocarbon, alcox C1-6, amino, hydroxy and cyanogen can be selected to replace the ring, Acid, C1-6, di - (C1-6 tar) amine,C1-6 alkylcarbonylamino, and oxo; R6 represents hydrogen, fluorine, or C1-6 alkyl; R7 represents hydrogen, fluorine, or C1-6 alkyl; or R6 and R7 together with the carbon atom to which they are attached form a ring of between 3 and 7 members that can be saturated or unsaturated, where the ring can optionally contain one or two heteroatoms selected from sulfur, oxygen, and nitrogen and where the ring may be optiona
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