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Diazepinona derivatives as mGluR5 Antagonists
专利权人:
NOVARTIS AG
发明人:
DIRK BEHNKE,DAVID CARCACHE,PETER ERTL,DAVID ORAIN,MANUEL KOLLER
申请号:
ARP130102989
公开号:
AR092212A1
申请日:
2013.08.23
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
As a drug and a drug to understand it. Claim 1: a formula compound (1) or a formula salt, wherein a is a single cycle ring system composed of 5 to 7 members, and its aromaticity, non aromaticity, saturation or unsaturation may include 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur; R 1 is halogen; cyanogen; nitrogen; Keywords hydroxyl group; amino group; - C (o) H; - C (o) nh482222;-X¹-R⁵;That's it.Keywords X1 from link; carbide; oxygen; sulfur; - S (o) -;-S (O) -1. Amino can be replaced by c833218331cf832424244j asphalt;-NH-C (O) --C (O) -NH--C (O) O--O-C (O) --NH-S (O) --S (O) -NH-y -NHC (O) NH-R⁵ is C₁₋₆ alkyl;a. Halogenated tar c83218d31832626;C₁₋₆ cyanoalkyl;Cbox carboxyalkyl;e. Hydroxyl oxidation c83217c831832626;C₁₋₄-C₁₋₆-alkoxy;C₁₋₄-alkoxy-C₁₋₄-alkoxy-C₁₋₆ alkyl;C₁₋₄carbonyl-C₁₋₆ alkyl;alcoxi C carbonil-alquilo C1. C833218d833124; - carbon tar c83321218d833262;C₁₋₆ aminoalkyl;alquil C amino-alquilo Cdi (alquil C) amino-alquilo Caminocarbonyl-C₁₋₆ alkyl;C₁₋₄-aminocarbonyl-C₁₋₆ alkyl;di (C₁₋₄ alkyl) aminocarbonyl-C₁₋₆ alkyl;C₁₋₄carbonylamino-C₁₋₆ alkyl;alquil C aminosulfonil-alquilo Cdi (alquil C) aminosulfonil-alquilo CC₂₋₆ alkenyl;C₂₋₆ haloalkenyl;1. C83228331 asphalt;C₂₋₆ haloalkynyl;X2 is link or tenant c832131;a. The carbon atom of tar c83218331-832323 can be replaced by a group selected by carbon, oxygen, sulfur and S (o);-S (O) -1. Amino can be replaced by c833218331cf832424244j asphalt;-NH-C (O) --C (O) -NH--C (O) -O--O-C (O) --NH-S (O) --S (O) -NH-y -NHC (O) NH-B² is a three to seven membered monocyclic ring system that can be aromatic, non-aromatic, saturated or unsaturated and can contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, where the ring system can in turn be replaced once or more than once by R⁶;each R⁶ independently is halogen, hydroxyl, cyano, C₁₋₄ alkyl,C₁₋₄ haloalkyl,C₁₋₄ alkoxy,or C₁₋₄ haloalkoxy;O in the same ring atom, two r8310s are equal to oxo; m is equal to 0, 1, 2, 3 o r 4; each R 2 is independen
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