The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.本發明涉及糖尿病領域。更具體地,本發明涉及聚乙二醇化的賴脯胰島素化合物,其是用高分子量聚(乙二醇)進行了聚乙二醇化的、在生理pH是高度可溶的、具有延長的作用持續時間、和特徵在於藥物代謝動力學、藥物動力學和/或活性峰谷比小於2。本發明還涉及提供此類分子的方法、涉及含有它們的藥物組合物、並涉及它們的治療性用途。
