WALKER, DANIEL,PIOTROWSKI, DAVID,JACOBSEN, ERIC,ACKER, BRAD,WISHKA, DONN,REITZ, STEVEN CHARLES,GROPPI, VINCENT
申请号：
ES02778286
公开号：
ES2383001T3
申请日:
2002.10.01
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of Formula I: Formula I in which Azabicyclo is or W is or with the proviso that the bond between the group -C (= X) - and the group W can be attached to any available carbon atom in the group W provided in R3, R6 and R15； X is O, or S； R0 is H, lower alkyl, substituted lower alkyl or halogenated lower alkyl； Each R1 is H, alkyl, cycloalkyl, halogenated alkyl, substituted phenyl or substituted naphthyl； Each R2 is alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, aryl, F, Cl, Br, I or R2 is absent with the proviso that k2, k5 or k6 is 0； R2-3 is H, alkyl, substituted alkyl, halogenated alkyl, F, Cl, Br or I； k2 is 0 or 1； k5 and k6 are independently 0, 1 or 2； A --- A '--- A "is N (R4) -C (R3) = C (R3), N = C (R3) -C (R15) 2, C (R3) = C (R3) N (R4), C (R3) 2-N (R4) -C (R3) 2, C (R15) 2-C (R3) = N, N (R4) -C (R3) 2-C (R3) 2 , C (R3) 2-C (R3) 2-N (R4), OC (R3) = C (R3), OC (R3) 2-C (R3) 2, C (R3) 2-OC (R3) 2, C (R3) = C (R3) -O, C (R3) 2-C (R3) 2-O, SC (R3) = C (R3), SC (R3) 2-C (R3) 2, C (R3) 2-SC (R3) 2, C (R3) = C (R3) -S, or C (R3) 2-C (R3) 2-S； Each R3 is independently a link to the core molecule with the condition that only one R3 and no R6 or R15 is also said bond, H, alkyl, substituted alkyl, halogenated alkyl, alkenyl, substituted alkenyl, halogenated alkenyl, alkynyl, substituted alkynyl, halogenated alkynyl, -CN, -NO2, F , Br, Cl, I, -OR19, -C (O) N (R10) 2, -N (R10) 2, -SR19, -S (O) 2R19, -C (O) R19, -CO2R19, aryl, R7 or R9； J, L, M and Q are N or C (R6) with the proviso that only one of, L, M or Q, is N and the others are C (R6), additionally with the condition that when the core molecule is attached the pyridinyl moiety in M, Q is C (H), and additionally with the proviso that there is only one binding to the core molecule； G and Y are C (R6), with the proviso that when the molecule is attached to the phenyl moiety in Y, G is CH； R4 is H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, halogenated cycloalkyl, substituted cycloalk
