YOUNG, TAI HORNG,杨台鸿,楊台鴻,CHUNG, YI CHEN,锺易辰,鍾易辰,CHEN, CHI RUEI,陈启瑞,陳啟瑞
申请号：
TW099122936
公开号：
TW201201841A
申请日:
2010.07.13
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Disclosed is a carrier complexes for object delivery comprised of an cationic carrier having an object to be delivered and coating by single stranded oligonucleotides. The carrier complexes is prepared by coating single-stranded oligonucleotides on the cationic carrier to reverse the surface charge, thereby effectively increasing transfection efficiency of the carrier complexes with low cell toxicity and thus is applicable to gene and drug delivery or manufacture of targeted drug.一種用於傳遞物質之載體複合物,包含具有待傳遞物之陽離子型載體以及包覆該陽離子型載體之單股核酸。該載體複合物係利用單股核酸包覆陽離子載體形成複合物,並使該載體複合物表面呈現陰電性,除了有效提高該載體複合物之細胞穿透性,且細胞毒性低,適合應用於基因轉殖、藥物投遞、或用於製造標靶藥物。
