Peter Kresten Nielsen,Frantisek Hubalek,Inger Lautrup-Larsen,Svend Ludvigsen,Ulla Ribel-Madsen,Per Balschmidt,Per Nørgaard,Svend Havelund
申请号：
US12442190
公开号：
US09018161B2
申请日:
2007.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
