Gnetum extract which can be obtained from Gnetum fruit or Gnetum seeds that provide antimicrobial action and antioxidative effect (radical scavenging action) without carrying out special operation. The relevant Gnetum extract has various physiological (pharmacological) actions and can be used as active ingredients of foods, nourishments (nutritional supplements), medicines, cosmetics, etc. In addition, Gnetum extract is obtained by immersing sliced or ground Gnetum fruit or Gnetum seeds in water or water containing organic solvent and aging.