PURPOSE: A cosmetic composition containing culture product of Magnolia sieboldii stem cells is provided to suppress MMP-1 generation and to ensure anti-aging, anti-wrinkling, skin whitening, and skin moisturizing. CONSTITUTION: A cosmetic composition contains culture product of Magnolia sieboldii stem cells as an active ingredient. The culture product is obtained by culturing stem cells from stem, leaves, roots, and flower bud of Magnolia sieboldii or pulverizing the cultured stem cells. The content of culture product is 0.00001-30 weight% based on total weight of the cosmetic composition. The cosmetic composition is manufactured in the form of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, cleansing, oil, powder foundation, wax foundation, pack, or spray.본 발명은 천녀목란 줄기세포 배양산물을 유효성분으로 함유하는 화장료 조성물을 제공한다. 본 발명의 천녀목란 줄기세포 배양산물은 세포 활성 증진효과 및 콜라겐 합성과 MMP-1 생성억제 효과가 뛰어나며 천녀목란 줄기세포 배양산물을 함유하는 화장료 조성물은 피부 노화방지, 주름개선, 피부미백, 피부보습 및 피부보습을 통한 아토피 개선에 뛰어난 효과가 있다.