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Antibodies that inhibit metalloproteins
专利权人:
Tamar Danon;Irit Sagi;Netta Sela-Paswell;Raanan Margalit
发明人:
Irit Sagi,Netta Sela-Paswell,Tamar Danon,Raanan Margalit
申请号:
US13521452
公开号:
US08697078B2
申请日:
2011.01.27
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present application relates to antibodies which recognize [2(2-aminoethylcarbomoyl)-ethoxymethyl]-tris-[2-N-(3-imidazol-1-yl-propyl))-ethoxymethyl]methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases.An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.
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