David John Madge;John Ford;John Frederick Atherall;Nicholas John Palmer;Derek John
发明人:
John Ford,Nicholas John Palmer,John Frederick Atherall,David John Madge,Derek John
申请号：
US12543151
公开号：
US08193215B2
申请日:
2009.08.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compounds of the formula:wherein R1 is aryl, heteroaryl, cycloalkyl or alkyl；R2 is H, alkyl, nitro, CO2R7, CONR5R6 or halo；R3 and R4 are H, NR5R6, NC(O)R7, halo, trifluromethyl, alkyl, CONR5R6, CO2R7, nitrile or alkoxy；R5 and R6 may be the same or different and may be H, alkyl, aryl, heteroaryl or cycloalkyl； or R5 and R6 may together form a saturated, unsaturated or partially saturated 4 to 7 member ring, wherein said ring may optionally comprise one or more further heteroatoms selected from N, O or S；R7 is H or alkyl；A is H, halo, or a group of formula X-L-Y；X is O, S or NR8；R8 is H or alkyl；L is (CH2)n, where n is 0, 1, 2, 3 or 4； andY is aryl, a heterocyclic group, alkyl, alkenyl or cycloalkyl；the products of mono- and di-oxidation of sulphur and/or mono-oxidation of nitrogen moieties in compounds of formula I；or a pharmaceutically acceptable salt thereof.These compounds find use as inhibitors of potassium ion channels and thus are useful in the treatment of various conditions including arrhythmia and type-2 diabetes mellitus.
