PROBLEM TO BE SOLVED: To provide methods for producing Monascus purpureus in which the content of useful bioactive substances, such as GABA and monacolin K, is enhanced.SOLUTION: Provided is a production method of Monascus purpureus comprising a multistage cultivation process in which a first co-koji obtained by culturing Monascus purpureus using grain as a substrate, and a first grain raw material are mixed and cultured, the Monascus purpureus obtained by the culture is used as a second co-koji, a second grain raw material is mixed to the second co-koji and further cultured, the Monascus purpureus obtained by the culture is used as a third co-koji, and a third grain raw material is mixed to the third co-koji and further cultured to produce Monascus purpureus.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】GABAやモナコリンKなどの有用な生理活性物質の含有量が高められた紅麹を製造する方法を提供する。【解決手段】穀物を基質として紅麹菌を培養して得た第1共麹と第1穀物原料とを混合して培養し、該培養によって得られた紅麹を第2共麹として、第2共麹に対して第2穀物原料を混合してさらに培養し、該培養によって得られた紅麹を第3共麹として、第3共麹に対して第3穀物原料を混合してさらに培養して紅麹を製造する多段培養工程を含む紅麹の製造方法である。【選択図】図1
