The method of the present invention especially reduces stomach and intestine immunerelated adverse events, such as colitis, diarrhea, carries out immune processing in object, such as immune oncology treatments, such as-CTLA4 antibody and anti-PD-1 antibody combinations treat melanoma. In is in some terms, method includes giving the inhibition MAdCAM integrins combination of polypeptide one of therapeutically effective amount, such as 4 β of anti alpha, 7 alpha 2 integrin antibodies, this vedolizumab or associated antibodies.
