Provided is a polymer micro-needle array chip comprising a micro-needle array and a substrate on which the micro-needle array is placed a polyacrylamide polymer with a molecular weight of 1.0x104-2.0x105, Vickers hardness of 150-600 HV and impact strength of 5-30 J/m is used as the material of the micro-needle array. The polymer micro-needle array chip has high mechanical strength and a sharp needle tip and it can easily be dissolved or can swell on contact with a water-containing environment, which helps the drug to be released slowly in the skin.