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High affinity metal-oxide binding peptides with reversible binding
专利权人:
发明人:
Erik Mark Krauland,Stephen Kottmann,Roberto Juan Barbero,Angela Belcher
申请号:
US14034420
公开号:
US09550809B2
申请日:
2013.09.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A dodecamer peptide, and its modified variant, having a repeating glycine-lysine sequence was created and found to bind with high affinity to oxide surfaces and certain activated polymeric surfaces. Reversible binding characteristics of the peptides were demonstrated. The peptides were integrated with proteins, cells and fusion proteins to provide attachment of the proteins, cells and fusion proteins to solid material structures. The peptides can be used to functionalize surfaces of components within mechanical, biomechanical, micro fluidic, electronic, bioelectronic, bio-optical, and biochemical devices. Experiments were carried out to assess functionalization and reusability of a suspended mass resonators cantilever.
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