Manuel L. Penichet,Rosendo Luria-Perez,Gustavo Helguera
申请号：
US13581369
公开号：
US20120321589A1
申请日:
2011.03.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are polypeptides which comprise all or part of an antibody linked to all or part of a cytokine. The cytokine sequences of the polypeptides have a modified heparin binding region which disrupts, inhibits, or reduces the ability of the cytokine to bind a heparin compound as compared to a corresponding cytokine having an unmodified heparin binding region. Also disclosed are methods of treating cancer, inducing cell proliferation, and reducing the non-specific binding and/or non-specific localization of the polypeptides.
