University of Medicine and Dentistry of New Jersey
发明人:
Ma, Jianjie,Weisleder, Noah
申请号：
AU2012233059
公开号：
AU2012233059A1
申请日:
2012.09.27
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012233059A120121025.pdf#####Abstract Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal muscle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorder, including those related to the normal aging process. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced. Figure 1A Eco" P,1- pTLcG-FgMG29 v2 (10.8 kb) ....... n . ... A" A=" gem destneed EcoRI PUIProbe I Probe 2 u 1.1kb 9.7kb B Previous GFP cassette Inveried GFP cassette FIGURE 1 1/18
