Ostergaard, Henrik,Gandhi, Prafull S.,Olsen, Ole Hvilsted
申请号：
AU2014336252
公开号：
AU2014336252A1
申请日:
2014.10.15
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to modified human coagulation Factor VII polypeptides having coagulant activity, especially variants having higher proteolytic activity and reduced antithrombin reactivity (increased resistance to inactivation by anti-thrombin) when activated as compared to wild-type FVIIa. The variants have certain substitutions at position T293 of mature human FVII in combination with specifc substitutions at L288, W201 and/or K337. The claims are also directed to pharmaceutical compositions, and medical uses of said factor VII polypeptides.
