Eli M. Wallace;Hong-Woon Yang;Joseph P. Lyssikatos;James F. Blake
发明人:
James F. Blake,Joseph P. Lyssikatos,Hong-Woon Yang,Eli M. Wallace
申请号：
US12356441
公开号：
US08431574B2
申请日:
2009.01.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are compounds of the Formulas III and IVand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
