A method for the treatment of pain, in particular antinociceptive or anti-allodynic treatment of pain, in a patient in need of such treatment, e.g. apatient with osteoporosis or osteopenia, a tumour patient or a patientsuffering from an inflammatory disease, which comprises administering aneffective amount of a bisphosphonate, e.g. zoledronic acid or salts orhydrates thereof, to the patient.