Wantanee Phuapradit;Zhongshui Yu;Navnit Hargovindas Shah;Hashim Ahmed;Martin Howard Infeld;Lewis Bender;Shingai Majuru
发明人:
Hashim Ahmed,Lewis Bender,Martin Howard Infeld,Shingai Majuru,Wantanee Phuapradit,Navnit Hargovindas Shah,Zhongshui Yu
申请号：
US12504484
公开号：
US09370492B2
申请日:
2009.07.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides novel solid pharmaceutical dosage forms for oral administration comprising a bisphosphonate, or a pharmaceutically acceptable salt thereof, which bisphosphonate is present in an amount not therapeutically effective when the bisphosphonate is orally administered alone, and a modified amino acid carrier, or a pharmaceutically acceptable salt thereof, which modified amino acid carrier is present in an amount effective to facilitate absorption of the bisphosphonate in the gastrointestinal tract such that the bisphosphonate is therapeutically effective. The ratio of bisphosphonate to modified amino acid carrier is from about 1:30 to about 1:1, respectively. These novel solid pharmaceutical dosage forms are useful in the treatment or control of bone diseases and particular disorders in calcium metabolism, including, for example, osteoporosis, hypercalcaemia of cancer, and the treatment of metastatic bone pain. The present invention also provides a method for treating these diseases employing the solid pharmaceutical dosage forms and a method for preparing the pharmaceutical dosage forms.
