The present invetnion develops a composition, which can be used daily, for inhibiting deterioration in skin condition, particularly the formation of wrinkles, associated with angiogenesis promoted by exposure to ultraviolet light. The present invention provides a composition for inhibiting angiogenesis promoted by exposure to ultraviolet light, said composition containing one or more types of compounds selected from a group comprising D-methionine, and a derivative and/or a salt thereof. The ultraviolet light may be UV-B. The angiogenesis may be inhibited by increased expression of thrombospondins (THBS) and/or decreased expression of vascular endothelial growth factor (VEGF). The composition may be external skin agents, cosmetics, wrinkle inhibitors, dermatological pharmaceuticals, or food.本發明開發一種可日常使用且用以抑制伴隨因曝露於紫外線而促進之血管新生所產生之皮膚狀態之惡化、尤其是抑制皺紋形成之組合物。本發明提供一種用以抑制因曝露於紫外線而促進之血管新生之組合物，其含有選自由D-甲硫胺酸與其衍生物及/或鹽所組成之群中之1種或2種以上之化合物。存在上述紫外線為UV-B之情況。存在上述血管新生係藉由血小板反應蛋白(THBS)之表現增強及/或血管內皮細胞生長因子(VEGF)之表現降低而受到抑制之情況。存在上述組合物為皮膚外用劑、化妝品、皺紋抑制劑、皮膚病用醫藥品、及食品等之情況。
