CLOUATRE, Daniel E.,BANGUN, Nimpan,CLOUATRE, Dallas L.
申请号：
EP17849647
公开号：
EP3509578A4
申请日:
2017.09.08
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Monomeric bimetal hydroxycitric acid (HCA) compounds are provided. The subject compounds include a divalent metal (X) bonded to the carboxylic acids of C2 and C3 and a monovalent metal (Y) bonded to the carboxylic acid of C1. Also provided are methods of preparing the subject compounds from a dimeric starting material (e.g., X3(HCA)2) which include acidifying the dimer to produce a monomeric intermediate which is subsequently neutralized with YOH base. Methods of alleviating at least one symptom associated with a target disease or condition in a subject are provided. Also provided are compositions including the subject monomeric bimetal HCA compounds which find use in a variety of therapeutic applications.
