ALAM, Jenefer,POULSEN, Anders,HO, Soo Yei,WANG, Wei Ling,DURAISWAMY, Athisayamani Jeyaraj
申请号：
SGSG2014/000601
公开号：
WO2015/094118A1
申请日:
2014.12.17
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph therof, including all tautomers and stereoisomers thereof wherein R1represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy)； optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo)； or -alkylaryl； R2 represents H； or alkyl； R3 represents H； or alkyl； U, V and W represent -(CH2)-； or U and V together represent -CH=CH- and W represents C=O； Y represents aryl； heteroaryl； optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo)； or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and-C(O)NHC1-6alkyl)； and Z represents aryl； heteroaryl； optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo)； or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6. alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and -C(O)NHC1-6alkyl).La présente invention concerne des composés de formule (I), des combinaisons et des utilisations correspondantes pour une thérapie de maladies ou un sel, un solvate ou un polymorphe pharmaceutiquement acceptable correspondant, comprenant tous les tautomères et stéréo-isomères correspondants, dans laquelle R1 représente alkyle éventuellement substitué (dans lequel les
