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貼劑
专利权人:
HISAMITSU PHARMACEUTICAL CO.; INC.
发明人:
TSURUDA, KIYOMI,鹤田清美,鶴田清美,YAMASOTO, SHINJI,山外真嗣,SHOHO, KOUKI,正宝幸喜,正寶幸喜,NAKANISHI, MASARU,中西胜,中西勝
申请号:
TW096128615
公开号:
TWI414299B
申请日:
2007.08.03
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m 2 ·24 hr measured at a temperature of 40°C and a relative humidity of 90%, and the methyl salicylate has a plasma AUC 0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean ± standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC 0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean ± standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m 2 and a contact area is 280 cm 2 .本發明係提供具備具有伸縮性之支持體,及於該支持體之至少單面上所層合之黏著劑層之貼劑,上述具有伸縮性之支持體係由施以捲縮加工之兩面目利安編(Medias織法)之織布而成,上述黏著劑層係以該層之總質量基準,含有10質量%以上之水楊酸甲酯,作為上述貼劑整體,以溫度為40℃,相對濕度為90%測定之透濕度為1~350g/m2.24hr,使上述黏著劑層之塗佈量為50~300g/m2,接觸面積為280cm2,貼附上述貼劑於人類皮膚8小時時,上述水楊酸甲酯於血漿中之AUC0-24之平均值±標準偏差之範圍為3.0~60.0ng.hr/mL,上述水楊酸甲酯代謝物之水楊酸於血漿中之AUC0-24之平均值±標準偏差之範圍為5000~13000ng.hr/mL之貼劑。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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