BUR, Daniel,GRISOSTOMI, Corinna,NAYLER, Oliver,REMEN, Lubos,VERCAUTEREN, Magali,WELFORD, Richard
申请号：
ES14799473
公开号：
ES2663124T3
申请日:
2014.11.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula (I) ** Formula ** Where X represents CH, or N； R represents hydrogen, (C1-4) alkyl, cycloalkyl (C3-6) alkyl, or trifluoroalkyl (C1-3)； R1 a and R 1 b independently represent hydrogen, methyl, ethyl； or R1 a and R 1 b j u n t o with the carbon atom to which they are attached to form a c-lopropyl ring； R2 represents r or lo or heteroaryl, where n aryl or heteroaryl is independently unsubstituted, or substituted once, twice or three times, when the substituents are independently selected from: - (C 1-4) alkyl； - (C 1-4) alkoxy； - c ic loalkyl (C 3-6), which optionally contains one or two m or s of oxygen in the ring； - f luoroalkyl (C1-3)； - f lu or r or alco xi (C 1-3)； - halogen； - cyano； - - (CH 2) n - N R 21 R2 2, where n represents the integer 0 or 1； and - R2 1 and R2 2 independently represent hydrogen or alkyl (C1-3)； or - R2 1 and R 2 2 together with the nitrogen nitrogen to which they are attached to form a saturated ring of 4 to 7 members, where an oxygen atom optionally contains an oxygen atom in the ring, and in where this ring is optionally substitute one or two fluoro substituents； - c arboxi； - -C O-NR2 3 R 2 4, where R2 3 and R2 4 independently represent hydrogen or (C 1-4) alkyl； - -C O- alkoxy (C 1-4)； - -N R25-CO-R2 6, and where R2 5 represents hydrogen or alkyl (C 1-4)； and R2 6 represents (C1-4) alkyl or a group -NR27R2 8 where R2 7 and R2 8 independently represent hydrogen or alkyd (C 1-4)； - hydroxy (C 1-4) alkyl； - (C 1-3) alkoxy (C 1-4) alkyl； - hydroxy-alkoxy (C 2-4)； - (C1-3) alkoxy (C2-4) alkoxy； - phenyl； - 5-membered heteroaryl； or - 3 -methoxy- or xe ta n -3-yl； R3 represents aryl or heteroaryl, wherein said aryl or heteroaryl is independently unsubstituted, or substituted once, twice, three or three times, where the substituents are independently selected from: - -N R4-SO 2 -Y- R 5, where -R4 represents hydrogen or (C1-3) alkyl； And it represents a direct link； and R5 represents (C 1-4) alkyl, or (C 3-6) cycloalkyl；
