FEIGE, ULRICH,LIU, CHUAN-FA,CHEETHAM, JANET,BOONE, THOMAS CHARLES
申请号：
CA2347131
公开号：
CA2347131C
申请日:
1999.10.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention concerns fusion of Fc domains with biologically activepeptides and a process for preparing pharmaceutical agents using biologicallyactive peptides. In this invention, pharmacologically active compounds areprepared by a process comprising: a) selecting at least one peptide thatmodulates the activity of a protein of interest； and b) preparing apharmacologic agent comprising an Fc domain covalently linked to at least oneamino acid of the selected peptide. Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. Thepreferred vehicle is an Fc domain. The peptide is preferably selected by phagedisplay, E. coli display, ribosome display, RNA-peptide screening, or chemical-peptide screening.
