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TPO MIMETIC PEPTIDES LINKED TO AN FC DOMAIN PROTEIN
专利权人:
INC.;AMGEN
发明人:
申请号:
IL14236501
公开号:
IL142365A
申请日:
2001.04.02
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising:a) selecting at least one peptide that modulates the activity of a protein of interest; andb) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide.Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide is preferably selected by phage display, E. coli display, ribosome display, RNA-peptide screening, or chemical-peptide screening.
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