Roger Francis Martin,Jonathan White,Pavel Lobachevsky,David Winkler,Colin Skene,Sebastian Marcuccio
申请号：
US15429348
公开号：
USRE046943E1
申请日:
2017.02.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula II, as follows:wherein W represents —N(R1R2) where R1 and R2 are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, —NHN(R1R2), —NHR3N(R1R2), —NHR3OR2, —N(R3)R3OR2, —N(R1)R3OR3OR3, —OR3NR1R2, —OR3 or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C1 to C4 alkyl, C2 to C4 alkenyl, —N(CO)N(R1R2), —N(CO)OR1, —N(CO)OR3OH, —(CO)NR1R2, —R3(CO)NR1R2, —R3OR1, —OR1, —N(R1R2) or —NH— R1 and R2 are the same or different and are selected from hydrogen, C1 to C4 alkyl or C2 to C4 alkenylR3 is a C1 to C4 alkyl or C2 to C4 alkenyl group or chainZ is the same or different and represents N or CHZ′ is the same or different and represents N or CX represents CH, N or NH, where is a double bond when X is CH or N and a single bond when X is NHX′ represents N or NH, wherein when X is CH or NX′ is NH and wherein X and X′ are different and further where is a double bond when X′ is N and a single bond when X′ is NHQ represents H, alkoxyl, —NR1R2, F or ClQ1 is absent when Z′ is N and when Z′ is C it represents H, alkoxyl, —NR1R2, F ClA represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatomsand pharmaceutically acceptable derivatives thereof.
