Martin, Roger Francis,White, Jonathan,Lobachevsky, Pavel,Winkler, David,Skene, Colin,Marcuccio, Sebastian
申请号：
AU2011238421
公开号：
AU2011238421A1
申请日:
2011.04.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula (II), as follows: wherein W represents -N(RR) where R and R are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, -NHN(RR), NHRN(RR), -NHROR, -N(R)ROR, -N(R)ROROR, ORNRR, -OR or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C to C alkyl, C to C alkenyl, -N(CO)N(RR), -N(CO)OR, -N(CO)OR3OH, -(CO)NRR, -R(CO)NRR, -ROR, -OR, -N(RR) OR -NH-； R and R are the or different and are selected from hydrogen, C to C alkyl or C to C alkenyl； group or chain； Z is the same or different and represents N or CH； Z' is the same or different and represents N or C； X represents CH, N or NH, where ⃜⃜ is a double bond when X is CH or N and a single bond when X is NH； X' represents N or NH, wherein when X is CH or N X' is NH and wherein X and X' are different and further where ≃≃≃is a double bond when X' is N and a single bond when X' is NH； Q represents H, alkoxyl, -NRR, F or Cl； Q is absent when Z' is N and when Z' is C it represents H, alkoxyl, -NRR, F or Cl； A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.
