MARTIN ROGER FRANCIS,WHITE JONATHAN,LOBACHEVSKY PAVEL,WINKLER DAVID,SKENE COLIN,MARCUCCIO SEBASTIAN
申请号：
IN8667/DELNP/2012
公开号：
IN2012DN08667A
申请日:
2012.10.05
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The invention relates to novel compounds processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula (II) as follows: wherein W represents N(RR) where R and R are not both hydrogen and where they may together form a 5 6 or 7 membered ring structure NHN(RR) NHRN(RR) NHROR N(R)ROR N(R)ROROR ORNRR OR or W represents piperidyl piperazinyl morpholinyl thiomorpholinyl or diazepanyl each of which may be optionally substituted by C to C alkyl C to C alkenyl N(CO)N(RR) N(CO)OR N(CO)OR3OH (CO)NRR R(CO)NRR ROR OR N(RR) OR NH R and R are the or different and are selected from hydrogen C to C alkyl or C to C alkenyl group or chain Z is the same or different and represents N or CH Z is the same or different and represents N or C X represents CH N or NH where ?? is a double bond when X is CH or N and a single bond when X is NH X represents N or NH wherein when X is CH or N X is NH and wherein X and X are different and further where ???is a double bond when X is N and a single bond when X is NH Q represents H alkoxyl NRR F or Cl Q is absent when Z is N and when Z is C it represents H alkoxyl NRR F or Cl A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position said ring including optional double bonds substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.
