A friction reduction apparatus (FRA) positioned onto a pipe string comprises a tubular housing, upper and lower mandrels having variously configured fluid flow passages and ports, a valve and a shifter. Fluid travelling through the apparatus causes the valve and shifter to reciprocate, repeatedly opening and closing flow passages. Each of these cycles creates a pulse in the fluid column creating vibrations that reduce friction in the pipe string. The FRA can be used in conjunction with a ball or dart activated tool positioned downhole from the FRA.