LONG, DANIEL D.,JIANG, LAN,SAITO, DAISUKE ROLAND,VAN DYKE, PRISCILLA
申请号：
ES08795593
公开号：
ES2465621T3
申请日:
2008.08.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of the formula (I): ** Formula ** (copy figure 1 - formula (I) - on page 2) where, A, is a five-membered heteroarylene ring, which contains one, two, three or four heteroatoms, selected from nitrogen, oxygen and sulfur, wherein, not more than one of the heteroatoms, is oxygen or sulfur； R1 is selected from -C (O) ORa, -C (O) NRbRc, C2-6 alkenyl, C1-6 alkyl, C3-12 cycloalkyl, and phenyl, wherein C1-6 alkyl is substituted, optionally, with one or two R3, C3-12 cycloalkyl, it is substituted, optionally, with or one or two halo, or with - ORa or NRbRc, and phenyl is substituted, in a way optionally, with one or two halo, or with - ORa, -NRbRc, or C1-4 alkyl, wherein, C1-4 alkyl, is optionally substituted, with - ORa； R2, is hydrogen or phenyl； R3, is selected from -C (O) ORa, -C (O) NRdRe, -ORf, -NRbRg, -CN, C3-6 cycloalkyl, phenyl, and naphthyl, where C3-6 cycloalkyl is substituted , optionally, with one or two halo, or with - ORa, and phenyl is optionally substituted, with one or two halo or with -CN； Ra, Rb, Rc, and Rd are, independently, hydrogen or C1-3 alkyl； Re, is hydrogen or C1-3 alkyl, optionally substituted with C3-6 cycloalkyl, -ORa, phenyl, pyridyl, or 4- phenylpiperazinyl； or Rd and Re, taken together with the nitrogen atom to which they are attached, form piperidinyl； Rf, is hydrogen, C1-3alkyl, or phenyl； Rg, is hydrogen or C1-3alkyl, optionally substituted with phenyl； and m, is 0, 1, or 2； with the proviso that, when m is 0, R2 is H； or a pharmaceutically acceptable salt thereof.Un compuesto de la fórmula (I):**Fórmula** (copiar figura 1 - fórmula (I) - de la página 2) en donde, A, es un anillo de heteroarileno de cinco miembros, el cual contiene un, dos, tres o cuatro heteroátomos, seleccionados de entre nitrógeno, oxígeno y azufre, en donde, no más de uno de los heteroátomos, es oxígeno o azufre； R1, se selecciona de entre -C(O)ORa, -C(O)NRbRc, alquenilo C2-6, alquilo C1-6, cicloalquilo C3-12, y fenilo, en donde el alquilo C1-6, se encuent
