1. Preparation, use as medicine and medicine containing such substance: a compound of formula (1): a-d-c (R1) 2-B (1), wherein each R1 is an independent hydrogen, C1-6 tar, C1-6 halo tar, c3-7 cyclododecane or c3-7 cyclododecane (C1-4 tar),Or two R1 and the carbon atoms they connect form a C3-4 cyclopentadiene ring； a is a single ring aromatic ring system composed of 5 to 6 members, which can contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and be replaced by R2 once or more； or a is a system. a. A bicyclic aromatic ring composed of 8 to 10 members, which may contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and may be replaced by R2 once or more； each R2 is an independent halogen, cyanogen, hydroxyl, amino, C1-6 tar, C1-6 halogen tar；hydroxyC 1-6 alkyl； C1-4 alkoxy-C1-6 alkyl； amino C1-6 alkyl； C1-4 alkyl-C1-6 alkyl； di- (C1-4 alkyl) -amino-C1-6 alkyl； C2-6 alkenyl； C2-6 halo-alkenyl； C2-6 alkynyl； C2-6 halo-alkynyl； C1-6 alkoxy； halo C1-6 alkoxy； C1-4 alkoxy-C1-6 alkoxy； C1-6-amino alkyl； di- (C1-6 alkyl) -amino； or a three to seven membered monocyclic ring system, which may be aromatic, saturated, or unsaturated unsaturated, which may contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and which may be substituted once or more than once by C1-6 alkyl, halo- C1-6 alkyl, C1-4 alkoxy-C1-6 alkyl, C1-6 alkoxy,C1-6 halo alcoxyl, halogen or cyanogen； or two R2 in the ring adjacent atoms together with these ring atoms form an unsaturated nonaromatic ring system composed of five to seven members, which may include one to four heteroatoms selected from nitrogen, oxygen and sulfur, And each R3 can be replaced by R3 one or more times； each R3 is an independent halogen, C1-6 tar or C1-6 alkane or two R3 in the ring atom, which are mixed oxides； B is a single ring aromatic ring system with 5 to 6 members, It may contain 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur,and that it is substituted once or more
