A method for synthesizing a medical grade biodegradable material, poly(lactic-co-glycolic acid), by biomass creatinine-catalyzed copolycondensation of lactic acid and glycolic acid. The present invention uses an in vivo arginine metabolic product, creatinine, as a catalyst, industrial grade lactic acid (LA, 85% aqueous solution) and glycolic acid (GA, 95%) as copolymerization monomers, and, through a solvent-free second-degree copolycondensation, acquires the high biosafety level, medical grade biodegradable poly(lactic-co-glycolic acid). The present invention is characterized in that: green technology is used, material costs are inexpensive, operation is simple and convenient, and industrial implementation is easy the catalyst, creatinine, has high levels of biocompatibility and biosafety, and no cytotoxicity, the poly(lactic-co-glycolic acid) synthesized is without any metal and other toxic residues the molecular weight of the poly(lactic-co-glycolic acid) synthesized is controlled within a range of between 1.8 and 17.7×104 and the poly(lactic-co-glycolic acid) synthesized is suitable for use as implantable material for hard tissue repair, surgical sutures, and targeted and controlled-release medicament carrier.La présente invention concerne un procédé pour synthétiser un matériau biodégradable de grade médical, poly(acide lactique-co-glycolique), par copolycondensation catalysée par la créatine de biomasse dacide lactique et dacide glycolique. La présente invention utilise un produit métabolique darginine in vivo, la créatinine, en tant que catalyseur, de lacide lactique (LA, solution aqueuse à 85 %) et de lacide glycolique (GA, 95 %) de grade industriel en tant que monomères de copolymérisation, et, par lintermédiaire dune copolycondensation de deuxième degré, sans solvant, pour obtenir du poly(acide lactique-co-glycolique) biodégradable de grade médical ayant un niveau élevé de biosécurité. La présente invention est caractérisée en ce que : une technologie vert
