JAMES WOOD,TE SOHN,ZHAOYONG IK - LU,ROUFAN LI,KYRIACOS C. NICOLAOU
申请号：
ARP160101973
公开号：
AR105193A1
申请日:
2016.06.29
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
On the other hand, this report also provides the preparation methods of these compounds. On the other hand, the present disclosure also provides pharmaceutical ingredients and methods of use of these compounds. In addition, an antibody drug copolymer containing a compound is also provided. 1. Claim 1: a formula compound (1),Among them: R1 is the substitute of - alkane C 8328 - (s) 739a3 or - alkane C 8328a3 - (s) 739a3； A3 is hydrogen or alkyl C 8321； 83222222；cycloalkyl C-8321；-8322C £ que alkenyl,C. leasehold 8321832222Arilo C,heteroaril Caral C-8321；-8322,acyl C £ ₁₂,or a substituted version of any of these groups； and x is 1, 2 or 3； R² is hydroxyl, or C £ alco alkoxy,aciloxyl C.-83281,O alternative version of any one of these groups； R3 is NHC (Y2) r18310；Where: Y2K is O, NH, O Noh； R1 8310c is alcoxyl C pounds；Alquenyloxy C-8328,C £ mino alkylamino,dialkylamino C.-83281,O alternative versions of any one of these substances； r83088 and r83099 are independently selected between hydrogen and halogen； X1 is O, s, or NH； A1 is - alkane c.8321； 832222-c (o) - A2 or - alkane c.8321； 832222-c (o) - A2 is alternative； or a formula compound (2) is x8308es-ch832283-o-o；R831222 is hydrogen, c-83282800cycloalkyl C.-83281,C C₈ substituted alkyl, or C £ £ substituted cycloalkyl； R⁹ is hydrogen, halo, hydroxyl, mercapto, C £₈ alkyl,C £ ₈ alkyl,Sustitude, alcohol C-8328,alcohol C-8328substituted, alkyl C-8328,E. replaced C asphalt； R1 83044 is hydroxyl, oxo, or R1 83044, which is used together with R1 and es-ocha 830808；2. When r83044 is oxo, r183044 and its attached carbon atoms are combined by a double layer, while r183044 is absorbed by R1, r83044 and its attached carbon atoms are combined by a single layer； a830808 is arilo c.83221； 8322o arilo c.83221； or A. the remaining formula (3), where x 830909es o, s, O NR 1831222；Among them, r831222 is hydrogen, and C rents 832828,substituted C £, alkyl, C £ ₈ acyl,or substituted C £₈ acyl； Z¹ is CH or N； and R¹⁷ is hydrogen, hydro
