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LIEURS DE CONJUGAISON SPÉCIFIQUE, IMMUNOCONJUGUÉS SPÉCIFIQUES DE CEUX-CI, PROCÉDÉS DE FABRICATION ET UTILISATIONS DESDITS CONJUGUÉS DE CEUX-CI
专利权人:
Suzhou M-conj Biotech Co., Ltd.;Hangzhou Dac Biotech Co. Ltd.;Zhao, Robert Yongxin
发明人:
ZHAO, Robert Yongxin,YANG, Qingliang,HUANG, Yuanyuan,GAI, Shun,ZHAO, Linyao,YE, Hangbo,GUO, Huihui,TONG, qianqian,CAO, Minjun,JIA, Junxiang,YANG, Chengyu,LI, Wenjun,ZHOU, Xiaomai,XIE, Hongsheng,LIN, C
申请号:
EP16715987
公开号:
EP3411074A4
申请日:
2016.02.04
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)- butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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