The present invention provides a method for reducing measurement interference of a micro biosensor (10), wherein the micro biosensor (10) is used to measure a target analyte in a biofluid during a period, and the period includes first sub-time zones and second sub-time zones. The method includes performing a interference eliminating action in the T1 zone, in which a second sensing section (131) of the micro biosensor (10) consumes an interferant, performing a measurement action in a first T2 zone, in which a first sensing section (121) of the micro biosensor (10) measures and outputs a physiological signal, performing the interference eliminating action in the next T1 zone to consume an interferant, performing the measurement action in the next T2 zone to measure and output a physiological signal, and so on, to obtain a value data of the physiological parameter in all respective T2 zones during the period, and to reduce a measurement interference.
