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Injectable biomaterials
专利权人:
Allergan Pharmaceuticals International Limited
发明人:
WEISS, Anthony Steven,MITHIEUX, Suzanne
申请号:
ES10750240
公开号:
ES2755902T3
申请日:
2010.03.10
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
Injectable composition formed from tropoelastine, wherein the composition includes a tropoelastin-containing substance, where the substance includes cross-linked tropoelastine and further includes an agent in the form of a polysaccharide or a polysaccharide derivative having an additional substitution or side chain comprising one or more groups consisting of hydrogen, alkyl, aryl, alkylaryl, arylalkyl, alkylaryl substituted with one or more oxygen, nitrogen, sulfur or phosphorous atoms; arylalkyl substituted with one or more oxygen, nitrogen, phosphorous sulfur, halogen or metal ion atoms; heterocycle substituted with one or more oxygen, nitrogen, sulfur, phosphorous, halogen or metal ion atoms and where said substituted groups can be directly linked to each other or separated by a member selected from the group consisting of ether, keto, amino, oxycarbonyl, sulfate, sulfoxide, carboxamide, alkyne and alkene; including, where such additional substitutions or side chains terminate with groups including but not limited to hydrogen, peptide, aldehyde, amine, arylazide, hydrazide, maleimide, sulfhydryl, active ester, ester, carboxylate, imidoester, halogen or hydroxyl, in an effective amount to provide the substance with flow properties that allow the composition to be injected.Composicion inyectable formada a partir de tropoelastina, donde la composicion incluye una sustancia que contiene tropoelastina, donde la sustancia incluye tropoelastina reticulada y ademas incluye un agente en forma de un polisacarido o un derivado de polisacarido que tiene una sustitucion o una cadena lateral adicional que comprende uno o mas grupos consistentes en hidrogeno, alquilo, arilo, alquilarilo, arilalquilo, alquilarilo sustituido con uno o mas atomos de oxigeno, de nitrogeno, de azufre o de fosforo; arilalquilo sustituido con uno o mas atomos de oxigeno, de nitrogeno, de azufre de fosforo, de halogeno o de ion de metal; heterociclo sustituido con uno o mas atomos de oxigeno, de nitrog
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