BERTEL Stiven Dzhozef,БЕРТЕЛ Стивен Джозеф,CHEN Li,ЧЭНЬ Ли,KORBETT Vendi Li,КОРБЕТТ Венди Ли,FEN Lichun,ФЭН Личунь,KHEJNS Nensi-Ellen,ХЭЙНС Ненси-Эллен,KESTER Robert Frensis,КЕСТЕР Роберт Френсис,SO S
申请号：
RU2012127273/04
公开号：
RU0002593369C2
申请日:
2010.12.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: pharmaceutics.SUBSTANCE: invention relates to compounds of formula (I):where: R1 is phenyl, unsubstituted or mono-or disubstituted independently halogen, cyano, C1-6 alkyl, alkoxy, -SO2CH3, -CF3, -C(CH3)2OH, -CH(CH3)OH, -C(CH3)(C(CH3)2)OH, -SO2(CH2)2OH, -NH(SO2CH3), -C(O)CH3, -C(CH2CH3)2OH, -N(CH3)2, -SO2CH(CH3)2, -SO2(CH2)2OCH2CH3, -SO2(CH2)2N(CH3)2, pyrasol or -SO2(CH2)2-morpholinium, 6-member heteroaryl containing 1 N heteroatom, unsubstituted or substituted C1-6 alkyl, alkoxy or -SO2CH3, or 2,3-dihydrobenzo[1,4]dioxine-6-yl R2 is C1-6 alkyl, 5-6-member heterocycloalkyl, containing 1 heteroatom selected from O, N, or C3-6-cycloalkyl, unsubstituted or substituted (=O) R3 is hydrogen, halogen, acyl group, cyano, C1-6 alkyl, unsubstituted or mono-, di- or three-substituted independently hydroxy, alkoxy, halogen, C1-6 alkyl, cyano, (=O) or -N(CH3)2, -OCH3, -OCH2C(O)N(CH3)2, -O(CH2)2OCH3, -O(CH2)2N(CH3)2, -OCH(CH3)2, -OC(CH3)2CH2OH, -OCH2CH2OH, -OC(CH3)2C(O)OCH2CH3, -OC(CH3)2C(O)OH, -CH2OC(O)CH2N(CH3)2, -NHC(O)CH2N(CH3)2 or -SO2-C1-6 alkyl connection between C1 and C2 is single or double bond X1 represents hydrogen, hydroxy, alkoxy or is absent, if the relationship between C1 and C2 is a double bond and X2 represents hydrogen or is absent, if the relationship between C1 and C2 is double bond, as well as their pharmaceutically acceptable salts.EFFECT: mentioned compounds and containing them pharmaceutical compositions are effective for treating metabolic diseases and disorders, such as, for example, type II diabetes mellitus.35 cl, 4 tbl, 141 exИзобретение относится к соединениям формулы (I):,где: R1 представляет собой фенил, незамещенный или моно- либо дизамещенный независимо галогеном, циано, С1-6 алкилом, алкокси, -SO2CH3, -CF3, -С(СН3)2ОН, -СН(СН3)ОН, -С(СН3)(С(СН3)2)ОН, -SO2(CH2)2OH, -NH(SO2CH3), -С(O)СН3, -С(СН2СН3)2ОН, -N(CH3)2, -SO2CH(CH3)2, -SO2(CH2)2OCH2CH3, -SO2(CH2)2N(CH3)2, пиразолом или -SO2(CH2)2-морфолином, 6-членный гетероарил, содержащий 1 гете
