Afatinib, optionally in the form of a pharmaceutically acceptable salt, including dimaleate salt

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专利权人:

WYETH HOLDINGS LLC

发明人:

申请号：

LU92407

公开号：

LU92407I2

申请日:

2014.03.19

申请国别(地区):

LU

年份:

2014

代理人:

摘要：

This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.

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