Substituted quinazoline derivatives and their use as tyrosine kinase inhibitors

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专利权人:

ワイス・ホールディングズ・コーポレイション

发明人:

アラン・ウィスナー,ホイ－ルー・チョウ,バーナード・ディーン・ジョンソン,フィリップ・ロス・ハマン,ナン・ジャン,ホイ-ルー・チョウ

申请号：

JP2014098765

公开号：

JP5830573B2

申请日:

2014.05.12

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.

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