The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Tran, Eric,Lu, Yong-Chen,Rosenberg, Steven A.
申请号：
AU2016323017
公开号：
AU2016323017A1
申请日:
2016.09.09
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
